RefCurv is a software package providing methods to create pediatric reference curves. Furthermore, it comes with a big number of diagnostic tools. The graphical user interface (GUI) is written in Python. RefCurv uses R and the GAMLSS add-on package as the underlying statistical engine.

The following figure shows example reference curves for Body Mass Index (BMI) over age:

The curves are based on a dataset of healthy Dutch boys. RefCurv was used to ﬁt a model to the data points and depict it in the form of percentile curves. The labels indicate the percentiles, e.g. “P3” stands for the third percentile.

**How does RefCurv work?**

RefCurv offers an easy-to-use interface that guides users through necessary steps for the construction of reference curves. Users do not need any programming experience.

RefCurv is **free of charge** and **open source**. You can find the code in the related GitHub repository.

As a user, you can load your data into RefCurv and analyze them in a scatter plot. You can select and deselect data points that should be considered for the reference curves. In some easy steps, you can fit a model to the data and plot the results as percentile curves.

**Publications**

RefCurv: A software for the construction of pediatric reference curves

Christian Winkler, Katharina Linden, Andreas Mayr, Thomas Schultz, Thomas Welchowski, Johannes Breuer und Ulrike Herberg

In: Software Impacts (Nov. 2020), 6 (100040)